Nuclear magnetic resonance based screening methods

Sillerud, L. O. and Larson, R. S. (2006) Nuclear magnetic resonance-based screening methods for drug discovery. Methods Mol. Biol. 316, 227-289. 

Mayer, M., and James, T. L. (2005). Discovery of ligands by a combination of computational and NMR-based screening RNA as an example target. In Nuclear Magnetic Resonance of Biological Macromolecules, Part C, Methods in Enzymology, 394, 571-587 Ed. Thomas L. James. 

The demand for enzyme assays that not only monitor overall activity but also en-antioselectivity stimulated the development of further assay systems that are still, however, in a rather experimental state with respect to high-throughput enzyme screening applications. These methods include assays based on electron spin resonance spectroscopy (ESR) [91], nuclear magnetic resonance (NMR) [92,93], IR-thermography [94] or electrospray ionization spectrometry (ESI-MS) [95]. 

Spectrometric methods are more often used for pesticide analysis in formulations. However, some spectrometry-based screening methods for environmental and biological samples have also been reported. Powerful structural elucidation spectrometric techniques (such as nuclear magnetic resonance spectrometry - NMR) have been also extensively used for the investigation of degradation... 

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