Zileuton NSAIDs

Administration of zafirlukast and aspirin increases plasma levels of zafirlukast, When zafirlukast is administered with warfarin, there is an increased effect of the anti coagulant. Administration of zafirlukast and theophylline or erythromycin may result in a decreased level of zafirlukast. Administration of montelukast with other drugs has not revealed any adverse responses. Administration of montelukast with aspirin and NSAIDs is avoided in patients with known aspirin sensitivity. Administration of zileuton with propranolol increases the activity or the propranolol with theophylline increases serum theophylline levels and with warfarin may increase prothrombin time (PT). A prothrombin blood test should be done regularly in the event dosages of warfarin need to be decreased. 

Figure VI-1-3 presents the pathways for the synthesis of PGe, PGE]( PGE2, PGF2a, IX Aj, and the i leukotrienes from the membrane phospholipids. It also shows the sites of action of the corticosteroids, i NSAIDS, COX 2 inhibitors, zileuton and zafirlukast, and other "-lukasts."...

---