NSAIDs Propoxyphene

The salicylates are beneficial for pain associated with inflammation, but their use has now been generally supplanted by other NSAIDs, largely because of gastrointestinal (GI) distress. Nevertheless, the salicylates are effective for treatment of mild to moderate pain and may produce analgesic effects comparable with those of weak narcotics such as propoxyphene hydrochloride. When used in combination with narcotics, the salicylates can be effective for severe pain accompanying acute ocular trauma or inflammation. 

Propoxyphene PO 100 mg q 4 h (napsylate) PO 65 mg q 4 h (HCI) (max. q day 600 mg of napsylate, 390 mg HCI) Use in moderate pain Weak analgesic most effective when used with NSAIDs or aspirin or acetaminophen Will cause carbamazepine levels to increase 100 mg of napsylate salt = to 65 mg of HCI salt... 

Furazolidone Metronidazole Minocycline Paromomycin Polymyxin B Salicylates and NSAIDs Loop diuretics Antitumor agents Miscellaneous Morphine Penicillamine Pentazocine Propranolol Propoxyphene... 

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