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Oxyphenbutazone Nortriptyline

The absorption of a single 400-mg dose of phenylbutazone in 4 depressed women was considerably delayed (time to maximum level, 4 to 10 hours compared with 2 hours), but the total amount absorbed (measured by the urinary excretion of oxyphenbutazone) remained unchanged when they were pretreated with desipramine 75 mg daily for 7 days. In another 5 depressed women the half-life of oxyphenbutazone was found to be unaltered by 75 mg of desipramine or nortriptyline dailyAnimal studies have confirmed that the absorption of phenylbutazone and oxyphenbutazone are delayed by the tricyclic antidepressants, probably because their antimuscarinic effects reduce the motility of the gut, - but there seems to be no direct clinical evidence that the antirheumatic effects of either drug are reduced by this interaction. No particular precautions appear to be needed. [Pg.158]

See other pages where Oxyphenbutazone Nortriptyline is mentioned: [Pg.62]    [Pg.80]    [Pg.134]    [Pg.174]    [Pg.209]    [Pg.344]    [Pg.647]    [Pg.702]    [Pg.729]    [Pg.761]    [Pg.816]    [Pg.904]    [Pg.947]    [Pg.1069]    [Pg.1198]    [Pg.1220]    [Pg.1331]    [Pg.1365]    [Pg.1392]    [Pg.1461]    [Pg.80]    [Pg.174]    [Pg.209]    [Pg.344]    [Pg.647]    [Pg.702]    [Pg.816]    [Pg.856]    [Pg.904]    [Pg.947]    [Pg.1069]    [Pg.1198]    [Pg.1220]    [Pg.1298]    [Pg.1331]    [Pg.1365]    [Pg.1424]    [Pg.1476]   
See also in sourсe #XX -- [ Pg.158 ]



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Nortriptyline

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