Norfenfluramine derivatives

Bromothymol blue (6.0...7.6) acid lipids, cholesterol glucuronides and gangliosides [241] aryloxybutanolamine derivatives [242] norfenfluramine derivatives [243] ethylamphetamines [244] in volatile mineral oil hydrocarbons [245] phospholipids [91]... 

Nitrous fiunes reagent 225, 226 Nondestructive detection 42 ff -with fluorescent reagents 44 -with iodine 46 -with pH-indicator 45 Noradrenaline 76, 240, 393 — 396 Norephedrine 76 Norfenefnne 76 Norfenfluramine derivatives 45 1 l-Nor-d -THC-9-carboxy lie acid 289,292 Novonal 339 Nucleosides 364... 

In addition to the pathways described above, nitrones can derive from condensation of a primary hydroxylamine with an aldehyde or ketone140. Under simulated biological conditions, Beckett and coworkers were able to demonstrate that primary hydroxylamines metabolically formed from amphetamine, mexiletine or norfenfluramine readily combined with ketones produced by metabolic deamination of the primary amines141. Reactions can be formulated according to equation 13, where R1 = aryl, alkyl or aralkyl, and R2 = alkyl or H. 

Disposition in the Body. Readily absorbed after oral administration and accumulates in the tissues. The major metabolite in the blood is the A-desethyl derivative, norfenfluramine, which is active. It is also metabolised by oxidation to m-trifluoromethyl-benzoic acid which is conjugated with glycine to form m-trifluoromethylhippuric acid. The rate of elimination is influenced by urinary pH and urinary flow. In acidic urine about 23% of a dose is excreted unchanged, and about 17% as norfenfluramine in 48 hours the remainder consists of m-trifluoromethylhippuric acid in alkaline urine about 2% is excreted as unchanged drug and norfenfluramine when the urinary pH is not controlled, 3 to 10% may be excreted as unchanged drug and 3 to 14% as norfenfluramine. Up to 5% of a dose is eliminated in the faeces as fenfluramine and norfenfluramine. 

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