NORel polymers

PUs offer several applications in blood-contacting devices. Many strategies have been studied to create localized NO release/generation from various PU materials. As discussed above, NORel polymers are prepared by covalently or noncovalently incorporating NO donor molecules into polymer matrices. Diazeniumdiolates have been incorporated into polymers for a variety of potential applications. Taite et al.. 

Figure 14.6 Two examples of NO-releasing (NORel) polymers where NO donor molecules (e.g., RSNOs or diazeniumdiolates) can be covalently or noncovalently incorporated into the PU. NO-generating (NOGen) polymers consist of immobilized catalysts that can generate NO from endogenous RSNO species.

Figure 14.7 Schematic of the assembled extracorporeal circulation (ECC) circuit and cross section showing generic coatings. Inner walls of the Tygon tubing and angiocatheters are coated with an active coat (containing the NORel or NOGen chemistry) or control coat (without NO chemistry), followed by a polymer top coat.

M.G. Norell, H.S. Andersson, LA. Nicholls, Theophylline molecularly imprinted polymer dissociation kinetics A novel mechanism sustained release drug dosage, /Mol Recognit, 11, 98-102, 1998. 

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