Noradrenaline lipid mobilization

Phentolamine antagonizes the lipid-mobflizing effects of adrenaline and noradrenaline in vivo and in vitro (Schotz and Page, 1960 Wenke et al., 1961 Stock and Westermann, 1965). Furthermore, phentolamine has been reported to exert a somewhat feeble lipid-mobilizing effect in vivo (Boshart et al., 1964) and in vitro (Wenke et al., 1963). 

Fig. 3. Influencing of lipid-mobilizing action of increasing concentrations of noradrenaline (NOR, abscissa) by constant concentrations of phentolamine (FEN) in vitro. Means SE. The high FEN concentrations and the depression of maxima indicating noncompetitive antagonism should be noted.

Fig. 7. Relative parameters of affinity of various catecholamine and oxedrine derivatives during influencing of lipid mobilization and tracheal relaxation in vttro. N = substitution of substances H = hydrogen Me = methyl Et = ethyl nPr = n-propyl nBu = n-butyl iPr z= isopropyl tBu = tert-butyl FtBu z= phenyl-tert-butyL Relative affinities of the substances in relation to that of noradrenaline are given in mean values SE. Left scale relative (logarithmic) pD values. The leveling out of the lipid-mobilizing effects of various catecholamines is to be noted. In the case of the oxedrines the effects are equalized over both functions.

Fig. 10. Dose-response curves of lipid-mobilizing actions of noradrenaline (NOR, left) and ACTH (right) antagonized by stated concentrations of the P-lytic agent propranolol (inderal, Ind.). Mean values SE. Parallel displacement of the noradrenaline curve by quite low concentrations of the lytic agent and pure depression of the ACTH effects are to be noted.

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