Noradrenaline-induced lipolysis

Recently, Arner and coworkers investigated the amount of perilipin protein and lipolysis rates in human subcutaneous adipocytes of non-obese and obese women [523]. A polymorphism in intron 6 (rs891460 A/G) in the perilipin gene seems to be associated with a 50% decrease in perilipin expression and increased basal lipolysis (AA vs. GG carriers) in adipocytes of the obese women, which in subjects matched for body mass index and adipocyte volume was inversely correlated with the plasma concentrations of NEFA and glycerol and thus may contribute to the development of insulin resistance. Furthermore, they found two- to four-fold increases in noradrenaline-induced lipolysis [523]. These data also reinforce the role of perilipin for the regulation of lipolysis in human fat cells. 

Gas Chromatographic Analysis of Non-esterified Fatty Acids in Serum of Normal, Diabetic, and Atherosclerotic Patients, Before and After Noradrenaline-Induced Lipolysis Rev. Atheroscler. Arteriopathies Peripheriques 9(3) 14-19 (1967) CA 70 85655k 134. 

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