Nonsteroidal antiinflammatory drugs phenylbutazone

The nonsteroidal antiinflammatory drugs like aspirin, indomethacin and phenylbutazone causes ulceration in gastro-intestinal tract which provides a site for bleeding in patients on anticoagulants. 

Aspirin (acetylsalicyclic add) causes irreversible acetylation of cyclooxygenase and inhibits the formation of PGs. Because mammalian platelets do not have a nucleus and the ability to carry out transcription and translation, they do not have the ability to resynthesize cyclooxygenase. New platelets must be formed, which takes several days. Other nonsteroidal antiinflammatory drugs (NSAIDs), such as indomethacin, ibuprofen, and phenylbutazone, also inhibit cylooxygenase by competing with the substrate AA at the active site. 

NSAIDs (nonsteroidal antiinflammatory drugs) Isolated cases of adverse neurological side effects have been seen with naproxen or phenylbutazone given with misoprostol. Misoprostol also increases the abdominal pain and other side effects of diclofenac and indometacin (indomethacin). Paracetamol (acetaminophen) intensifies pain if given with mifepristone and sulprostone used to induce abortion. 

Butyl-l,2-diphenylpyrazolidine-3,5-dione (phenylbutazone), a nonsteroidal antiinflammatory drug, is an efficient reducing cofactor for the peroxidase... 

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