Nonsteroidal antiinflammatory drugs indomethacin

Nonsteroidal antiinflammatory drugs Indomethacin, nalidixic acid... 

Nonsteroidal Antiinflammatory Drugs. Nonsteroidal antiinflammatory dmgs (NSAIDs) include, among the numerous agents of this class, aspirin (acetylsaflcyhc acid), the arylacetic acids indomethacin and sulindac, and the arylpropionic acids, (5)-(147) and (R)-(148) ibuprofen, (5)-(149) and (R)- (150), flurbiprofen naproxen (41), and fenoprofen (see Analgesics, antipyretics, and antiinflammatory agents Salicylic acid and related compounds). 

Nonsteroidal antiinflammatory drugs (NSAIDs) are the mainstay of therapy because of their excellent efficacy and minimal toxicity with shortterm use. There is little evidence to support one NSAID as more efficacious than another, and three drugs (indomethacin, naproxen, and sulindac) have FDA approval for this indication (Table 1-1). 

The nonsteroidal antiinflammatory drugs like aspirin, indomethacin and phenylbutazone causes ulceration in gastro-intestinal tract which provides a site for bleeding in patients on anticoagulants. 

Clinical use Indomethacin is a nonsteroidal antiinflammatory drug commonly used for the treatment of mild to moderate pain. It is also used in acute and chronic pain states such as rheumatoid arthritis, osteoarthritis,... 

Nonsteroidal antiinflammatory drugs (ketoprofen, naproxen, flurbiprofen, indomethacin, ibuprofen) CEC Hypersil C18/SCX, 3 pm Acetonitrile-50 mM Na2HPC>4-water (60 20 20) 210 mm x 50 pm i.d. 138... 

Aspirin (acetylsalicyclic add) causes irreversible acetylation of cyclooxygenase and inhibits the formation of PGs. Because mammalian platelets do not have a nucleus and the ability to carry out transcription and translation, they do not have the ability to resynthesize cyclooxygenase. New platelets must be formed, which takes several days. Other nonsteroidal antiinflammatory drugs (NSAIDs), such as indomethacin, ibuprofen, and phenylbutazone, also inhibit cylooxygenase by competing with the substrate AA at the active site. 

NSAIDs (nonsteroidal antiinflammatory drugs) Isolated cases of adverse neurological side effects have been seen with naproxen or phenylbutazone given with misoprostol. Misoprostol also increases the abdominal pain and other side effects of diclofenac and indometacin (indomethacin). Paracetamol (acetaminophen) intensifies pain if given with mifepristone and sulprostone used to induce abortion. 

Though the therapeutic utility of aspiri n has been recognized for well over a century, this venerable drug was not classified as a nonsteroid antiinflammatory until recently. The first drug to be so classified was in fact, indomethacin (1), a very useful agent introduced... 

Because of the resonance stabilization possible in its deprotonated form, the 5-tetrazolyl moiety is actually nearly as acidic (pKa ca. 6) as many carboxylic acids. This has led to its inclusion in many drug series as a carboxyl surrogate. Apparently related in concept to indomethacin (26a), intrazole (26) is a nonsteroidal antiinflammatory agent which also inhibits platelet aggregation, and therefore is of potential value in keeping the contents of the... 

Patches for local use include steroidal antiinflammatory ones with drugs such as betamethasone valeric acid or prednisone, and nonsteroidal type antiinflammatory ones with indomethacin and ketoprofene (not only pap drug but also tape type were commercialized), and lidocaine, which is used to reduce pain before an injection. Antiitch tape is also available as an over-the-counter medicine. 

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