Nonsteroidal antiinflammatory drugs flurbiprofen

Nonsteroidal Antiinflammatory Drugs. Nonsteroidal antiinflammatory dmgs (NSAIDs) include, among the numerous agents of this class, aspirin (acetylsaflcyhc acid), the arylacetic acids indomethacin and sulindac, and the arylpropionic acids, (5)-(147) and (R)-(148) ibuprofen, (5)-(149) and (R)- (150), flurbiprofen naproxen (41), and fenoprofen (see Analgesics, antipyretics, and antiinflammatory agents Salicylic acid and related compounds). 

Clinical use Flurbiprofen is a nonsteroidal antiinflammatory drug used for the treatment of pain and inflammation associated with musculoskeletal and joint disorders as well as neuralgias, dysmenorrhoea and postoperative pain. 

Nonsteroidal antiinflammatory drugs (ketoprofen, naproxen, flurbiprofen, indomethacin, ibuprofen) CEC Hypersil C18/SCX, 3 pm Acetonitrile-50 mM Na2HPC>4-water (60 20 20) 210 mm x 50 pm i.d. 138... 

Aryl propionic acid nonsteroidal antiinflammatory drugs. The compounds from this class of agents that have been stereochemically resolved include ibuprofen, flurbiprofen, naproxen, benoxaprofen, pirprofen, su-profen, fenoprofen, indoprofen, and ketoprofen (94). 

Flurbiprofen is a nonsteroidal antiinflammatory drug of the 2-arylpropionic acid class. The recommended dosages for flurbiprofen are 50 mg q. 4 to 6 hours for analgesia and 100 to 300 mg/day for the treatment of inflammatory conditions (see also Table 3). 

Nonsteroidal antiinflammatory drugs. Pirprofen, naproxen, ibuprofen, and keto-profen can occasionally cause microvesicular steatosis in humans (Bravo et al. 1997 Victorino et al. 1980 Danan et al. 1985 Dutertre et al. 1991). These NSAIDS have a 2-arylpropionate structure, with an asymmetric carbon, and exist as either the S(+)- or the R(—)-enantiomers. Only the S(+)-enantiomer inhibits prostaglandin synthesis, whereas only the R( )-enantiomer is converted into the acyl-CoA derivative. However, both the S(+)-enantiomer and the R( )-enantiomer of ibuprofen inhibit the p-oxidation of medium- and short-chain fatty acids (Freneaux et al. 1990). Pirprofen, tiaprofenic acid, and flurbiprofen also inhibit mitochondrial p-oxidation (Geneve et al. 1987a). 

Liu, J., Patel, S, Gillespie, D Whang, K and Couldwell, W. (2012) R-Flurbiprofen, a novel nonsteroidal antiinflammatory drug, decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro. J. NeurooncoL, 106, 561-569. 

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