Nonracemic intermolecular Pauson-Khand

Development of nonracemic intermolecular Pauson-Khand reactions has followed two directions. The first efforts addressed the generation of dissymmetric complexes of the form Co2(CO)5L alkyne, in which L is an enantiomerically pure ligand. Using (/ )-... 

A chiral auxiliary-based method employing heteroatom binding shows considerable promise in nonracemic intermolecular Pauson-Khand chemistry. Scheme 5-3 depicts an acetylene synthetic equivalent bearing the 10-methylthioisobomeol moiety (15), which is capable of significant asymmetric induction upon Pauson-Khand cycloaddition. Loss of carbon monoxide from 15 may be effected thermally, or better yet, by reaction with IV-methylmorpholine N-... 

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