Nonpolyene macrolides

No in vitro studies have been carried out specifically on the biosynthesis of the aminosugar moieties of polyene macrolide antibiotics however, the similarity with the biosynthesis of aminosugars of nonpolyene macrolides and bacterial lipopotysaccharides provides some data on the probable biosynthetic pathway. 

Polyene macrolides are synthesited (as are other, better known nonpolyene macrolides) from two- and three-carbon units activated as malcmyl-CoA and methylmakxiyl-CoA. A few polyene macrolides contain an aromatic moiety that derives from p-aminobenzoyl-CbA and is used as starter unit. The different precursor units are condensed by polyketide synthases. Aminosugars, for example, mycosamine or pero mine, are attached glycosidi-cally to the lactone ring. 

Martin, J.-F. Nonpolyene macrolide antibiotics. In Secondary Products of Metabolism (A. H. 

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