Nonlinear nonideal chromatography

Figure 1.16. Nonlinear nonideal chromatography. tQ = start of separation (point of sample injection) tR = retention time of component A tg = retention time of component B tn = time of emergence of mobile...

Using these two sets of conditions, we can then describe four chromatographic systems (a) linear ideal chromatography, (b) linear nonideal chromatography, (c) nonlinear ideal chromatography, and (d) nonlinear nonideal chromatography. 

FIGURE 2.17 Isotherms for nonlinear nonideal chromatography. Cs = concentration at surface or in stationary phase Cq = concentration in solution (mobile phase) at equilibrium. 

The ideal model of chromatography, which has great importance in nonlinear chromatography, has little interest in linear chromatography. Along an infinitely efficient column, with a linear isotherm, the injection profile travels unaltered and the elution profile is the same as the injection profile. We also note here that, because of the profound difference in the formulation of the two models, the solutions of the mass balance equation of chromatography for the ideal, nonlinear model and the nonideal, linear model rely on entirely different mathematical techniques. 

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