Nonlinear least-squares regression analysis kinetic data

The Nonlinear Least-Squares Regression Analysis of Kinetic Data... 

Toward these ends, the kinetics of a wider set of reaction schemes is presented in the text, to make the solutions available for convenient reference. The steady-state approach is covered more extensively, and the mathematics of other approximations ( improved steady-state and prior-equilibrium) is given and compared. Coverage of data analysis and curve fitting has been greatly expanded, with an emphasis on nonlinear least-squares regression. 

The mathematical solution of the pharmacokinetic model depicted by Figure 5 Is described by Equation 5, where K12 and K23 are first order rate constants analogous to Ka and Ke, respectively. This solution was applied to the data and "best fit" parameters estimated by Iterative computational methods. The "fit" of the data to the kinetic model was analyzed by least squares nonlinear regression analysis ( ). 

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