Nonclassical activation of carbon

Several studies on the structure-activity relationships (SAR) of cannabinoids have been recently published [34-37]. Three important features have been determined for classical and nonclassical cannabinoids a side-chain of three to seven carbon atoms in the 3-position of the phenol, a phenolic hydroxyl, and a suitable conformation or substituents in the C 9 position. However, not all these features are necessarily required to produce analgesic effects. 

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