Noncentrosymmetric achiral space group

In the case of a-oxoamides 22, meta-substituted amides exhibit a relatively high tendency of crystallization with the chiral framework [19c]. If both observations that meta-substituted arenes prefer to crystallize in noncentrosymmetric space groups, in comparison to the ortho- and para-isomers, have some generality, then meta-substitution in an achiral compound could be an important structural... 

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