Non-symmetric dinucleating ligands

NON-SYMMETRIC DINUCLEATING LIGANDS FOR OXIDATION CATALYSTS TEMPLATES FOR REALISTIC DINUCLEAR METALLOENZYME MIMICS... 

We present here a new entry into the synthesis of non-symmetric dinuclear transition metal complexes by making use of non-symmetric dinucleating ligands. The use of a non-symmetric dinucleating ligand will force the two metal ions in the resulting complex into different chemical or coordination environments. This will result in the formation of a more realistic enzyme mimic. 

In the second approach (scheme 9), a Mannich condensation on a substituted salicylaldehyde is followed by a two step or a single step reductive amination. Both yields and flexibility towards a diversity of non symmetric dinucleating ligands, such as 26 and 27, are greatly improved. 

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See also in sourсe #XX -- [ ]

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