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Non Steroidal Anti Inflammatory Drug

One of the virtues of the Fischer indole synthesis is that it can frequently be used to prepare indoles having functionalized substituents. This versatility extends beyond the range of very stable substituents such as alkoxy and halogens and includes esters, amides and hydroxy substituents. Table 7.3 gives some examples. These include cases of introduction of 3-acetic acid, 3-acetamide, 3-(2-aminoethyl)- and 3-(2-hydroxyethyl)- side-chains, all of which are of special importance in the preparation of biologically active indole derivatives. Entry 11 is an efficient synthesis of the non-steroidal anti-inflammatory drug indomethacin. A noteworthy feature of the reaction is the... [Pg.61]

Flufenamic acid (162) is a reasonably well-established NSAID (Non Steroidal Anti Inflammatory Drug). Alkylation of its potassiuni salt with the hydroxyethyl ethyl ether of ethylenechlo-rohydrin affords the latendated derivative etofenamate (163) [41]. Antiinflammatory activity is apparently retained when both rings in the fenamate series carry carboxyl groups. Thus, condensation of dichlorobenzoic acid 164 with anthranilic acid (165) by means of nucleophilic aromatic... [Pg.42]

Electropherograms of a urine sample (8 ml) spiked with non-steroidal anti-inflammatory drugs (10 p-g/ml each) after direct CE analysis (b) and at-line SPE-CE (c). Peak identification is as follows I, ibuprofen N, naproxen K, ketoprofen P, flurbiprofen. Reprinted from Journal of Chromatography, 6 719, J. R. Veraait et al., At-line solid-phase exti action for capillary electrophoresis application to negatively charged solutes, pp. 199-208, copyright 1998, with permission from Elsevier Science. [Pg.287]

Non-steroidal Anti-inflammatory Drugs Opioid Systems Local Anaesthetics Voltage-dependent Na+ Channels... [Pg.79]

Non-steroidal Anti-inflammatory Drugs. Figure 2 Physiological and pathophysiological functions of the COX... [Pg.873]

Schwaiger J, Ferling H, Mallow U, Wintermayr H, Negele R (2004) Toxic effects of non-steroideal anti-inflammatory drug diclofenac. Part I. Histopathological alterations and bioaccumulation in rainbow trout. Aquat Toxicol 68 141-150... [Pg.225]

Contrary to other elicitors of non-immune anaphylactic reactions (radiocontrast media, neuromuscular blocking agents, non-steroidal anti-inflammatory drugs (NSAIDs)) where there are at least hypothetical concepts regarding the pathomecha-nism of these reactions via increased mediator release (e.g. histamine release, shift in arachidonic acid metabolism from prostaglandins towards leukotrienes, etc.) [26], there is almost no literature regarding the pathomechanism of these reactions after LA application. [Pg.194]

Non-steroidal anti-inflammatory drugs cyclooxygenase 2 inhibitors... [Pg.12]

National High Blood Pressure Education Program noninsulin-dependent diabetes mellitus non-steroidal anti-inflammatory drug peripheral resistance... [Pg.31]


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Anti-inflammatory drugs

Anti-inflammatory drugs steroid

Anti-inflammatory drugs steroidal

Discovery of the Classical Non-steroidal Anti-inflammatory Drugs

Non Steroidal Anti

Non-steroid anti-inflammatory drugs

Non-steroid anti-inflammatory drugs

Non-steroid anti-inflammatory drugs Aspirin)

Non-steroid anti-inflammatory drugs NSAID)

Non-steroidal

Non-steroidal anti-inflammatories drug interactions

Non-steroidal anti-inflammatory

Non-steroidal anti-inflammatory drugs (NSAlDs)

Non-steroidal anti-inflammatory drugs NSAIDs)

Non-steroidal anti-inflammatory drugs clinical use

Non-steroidal anti-inflammatory drugs diclofenac

Non-steroidal anti-inflammatory drugs ibuprofen

Non-steroidal anti-inflammatory drugs naproxen

Non-steroidal anti-inflammatory drugs use in dental surgery

Non-steroidal anti-inflammatory drugs use in headache

Non-steroidal anti-inflammatory drugs use in osteoarthritis

Non-steroidal anti-inflammatory drugs use in rheumatism

Steroidal drugs

Steroids anti-inflammatories

Steroids, anti-inflammatory

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