Non-Nucleoside HIV Integrase Inhibitors

Responsible for the quick construction of two subunits through Click Reaction  

It is evident from the results that the click chemistry reaction methodology has been quite useful in the design of HIV-integrase inhibitors producing a promising new starting point for further elaboration and optimization 

17 Miscellaneous Therapeutic Segments 1,2,3-Triazole-Linked Dopamine D3 Receptor (D3R)-Setect/Ve Therapeutic Agents 

D3 receptor (D3R)-selective ligands may be used to treat a variety of neuropsychiatric disorders associated with aberrant dopamine signaling including schizophrenia [118], Parkinson s disease and associated dyskinesias [106,107,119,120], and drug addiction [121-123]. 

In the present series, indolyl-triazole 93 has the best overall profile in terms of D3R affinity, selectivity, lipophilicity, and metabolic stability. 

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Figure 2.26 Improved variants of L-708906 as non-nucleoside HIV integrase inhibitors.

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