Non-fivefold Symmetric Aryl Amide Macrocycles

The above result is also in line with further computational analyses, revealing 16-residue macrocycle to be the most stable. By alternatively performing the condensation reaction using not only monomeric reactants such as 10a but also 

Additional tuning in reaction conditions showed that the condensation reactions using only monomeric building blocks as the starting materials are, as expected, temperature-dependant with the yield for the thermodynamically more stable six-residue macrocycle 9 (Fig. 9.3a) decreasing from 65-80 % at -20 °C to 40 % at 20 °C and that of less stable macrocyclic octamer increasing from trace amount at -20 °C to 23 % at 20 °C [34]. 

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