Non-Enzyme-Catalysed Racemization

There have been developed several in situ racemization reaction such as proto-nation/deprotonation, addition/elimination, oxidation/reduction and nucleophilic substitution. 

Base catalysed racemisation is a straightforward approach because enzymes typically operate at pH close to 7. Clearly the relevant substrates must possess a stereogenic center with an acidic proton, such as a-substituted carboxylic acid derivatives [53-55]. 

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