Non-chemical Factors Affecting the Completion of Solid-phase Reactions

Fmoc amino acid Single bead FTIR Fmoc cleavage Compound cleavage 

Non-chemical Factors AfFecting the Completion of Solid-phase Reactions 

Many factors will prevent the reaction from completion and lower the yield of solid-phase synthesis. Besides chemical issues, factors hke solvent [8], reagent diffusion [9], mixing method [10], site interaction [11], and others may all influence the synthesis. In this section, discussion will focus on the reagent diffusion issue in solid-phase synthesis. 

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Non-chemical Factors Affecting the Completion of Solid-phase Reactions 507 Tab. 12.1 Comparison of on-bead and off-bead analysis. 

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