Non-anomeric sugar phosphates

Several chemical methods are available for the phosphorylation of suitably protected saccharides. The following approaches, classified according to the initial phosphorylation product, can be distinguished phosphotriester, phosphite triester and //-phosphonate methods. 

Properly protected phosphorochloridates have been employed, and examples include . bis(2,2,2-trichloroethyl) phosphorochloridate96 and dibenzyl phosphorochloridate.97 Phosphoroiodates prepared in situ by the oxidation of the corresponding trialkylphosphites with iodine can also be used.98 

Another reagent for the synthesis of //-phospho nates is tris(imidazo-lyl)phosphine,1 prepared from trichlorophosphine and imidazole in the presence of triethylamine. Again, the intermediate phosphite derivative is hydrolysed and the obtained //-phosphonate is converted to a phosphodiester as described above. 

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Sugar phosphates are widely found in nature and several classes can be identified. First, a distinction needs to be made between anomeric and non-anomeric sugar phosphates. Furthermore, natural sugar phosphates... 

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