Noguchi, Thomas

Thomas and Jackson [329] have shown that ebselen inhibited copper-initiated LDL oxidation in the presence of glutathione. Noguchi et al. [330] showed that the inhibitory effect of ebselen on copper-initiated LDL was also observed without glutathione, while in the case of radical-initiated LDL oxidation ebselen was inactive. However, it is possible that ebselen may inhibit both copper- and peroxyl radical-initiated LDL oxidation although in the latter case the inhibitory effect of ebselen depends on the size of peroxyl radical flux [331]. The inhibitory effect of ebselen on LDL oxidation also depends on its ability to reduce LDL hydroperoxides. 

Adapted with the permission of Simon Schuster from Coroner, by Thomas T. Noguchi, M.D., Copyright 1984 by Thomas Noguchi and Joseph DiMona. 

Dr. Thomas Noguchi, the renowned Los Angeles coroner, was performing an autopsy on a young man in his twenties who had been stabbed to death. A Los Angeles Police Department homicide detective entered the room, carrying a brown bag that held the fatal weapon. Do you want to take a look at it he asked. 

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