NMN, p-nicotinamide mononucleotide

Figure 11.9. ISAD synthesis pathway from nicotinamide or niacin (l)nicoti-namidase (E.C. 3.5.1.19) (2)nicotinamide phosphoribosyl transferase, which requires ATP (3)1SIMN adenyl transferase, which requires ATP (4) nicotinic acid phosphoribosyl transferase, which requires ATP (5) NMN adenyl transferase, which requires ATP (6) NAD synthetase, which requires ATP. Ri, ribose P, phosphate Ad, adenine NMN, nicotinamide mononucleotide. This figure is from Ref 33 and is used with permission.

Key AcK, acetate kinase AdK, adenylate kinase NAD-PP, NAD pyrophosphorylase PPase, pyrophosphorylase NADK, NAD kinase r-5-P, ribose-5-phosphate rA-5-P, ribosylamine-5-phosphate NMN, nicotinamide mononucleotide AcP, acetyl phosphate FPi, pyrophosphate and NDC, N J(2,4-dinitrophenyl)-3-carbamoylpyridinium chloride. 

Figure 2 NAD metabolism. Tip = tryptophan, 3-HK = 3-hydroxykynurenine, 3-HA = 3-hydroxyanthranilic acid, ACMS = a-amino-P-carboxymuconate- -semialdehyde, AMS = a-aminomuconate- -semialdehyde, NaMN = nicotinic acid mononucleotide, NMN = nicotinamide mononucleotide, NaAD = nicotinic acid adenine dinucleotide. For other abbreviations, see Figure 1. (1) tryptophan oxygenase [EC 1.13.11.11], (2) formy-dase [EC 3.5.1.9], (3) kynurenine 3-hydroxylase [EC 1.14.13.9], (4) kynureninase [EC 3.7.1.3], (5) 3-hydroxyanthranilic acid oxygenase [EC 1.13.11.6], (6) nonenzymatic, (7) aminocarboxymuconate-semialdehyde decarboxylase [EC 4.1.1.45], (8) quinolinate phos-phoribosyltransferase [EC 2.4.2.19], (9) NaMN adenylyltransferase [EC 2.7.2.18], (10) NAD synthetase [EC 6.3.5.1], (11) NAD kinase [EC 2.7.1.23], (12) NAD" glycohydro-lase [EC 3.2.2.5], (13) nicotinamide methyltransferase [EC 2.2.1.1], (14) 2-Py-forming MNA oxidase [EC 1.2.3.1], (15) 4-Py-forming MNA oxidase [EC number not given], (16) nicotinamide phosphoribosyltransferase [EC 2.4.2.12], (17) NMN adenylytransferase [EC 2.7.71], (18) nicotinate phosphoribosyltransferase [EC 2.4.2.11], (19) nicotinate methyltransferase [EC 2.7.1.7], and nicotinamidase [EC 3.5.1.19]. Solid line, biosynthesis dotted line, catabolism.

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