Nitrous oxide disadvantages

A disadvantage of supercritical fluids for extraction is that most common fluids used for extraction (carbon dioxide, nitrous oxide, sulfur hexafluoride, etc.) are weak solvents, limiting the polarity and molecular weight range of analytes that can be efficiently extracted. Also, for trace analysis the availability of fluids of adeguate ptirity may be a problem. 

Nitrous oxide is the only inhalation anesthetic that is a gas. It is chemically inert. Nitrous oxide has little effect on overall cardiovascular function. Disadvantages are that it has no muscle relaxing effect and that it cannot be used on its own because of high Minimal Alveolar Concentration values needed for adequate anesthesia. During recovery there is a risk for hypoxia and anesthesia should be slowly tapered off to prevent this event. 

Because of its slow induction and recovery, irritant property and other disadvantages ether is rarely used these days and may be occasionally used as a supplement to nitrous oxide-oxygen mixture in children. 

Disadvantages. Nitrous oxide is expensive to buy and to transport. It must be used in conjuction with more potent anaesthetics to produce full surgical anaesthesia. 

In the recent past, the focus of new developments was on alternative phenol processes that overcome the disadvantage of the coupled product acetone in the cumene oxidation process. These processes are based on the oxidation of benzene with nitrous oxide or hydrogen peroxide [7]. The main research on the cumene oxidation process is process intensification by improving the oxidation reaction and improved process and reactor design. 

The packed column suppressor, originally introduced by Small et al., suffers from a number of drawbacks, such as time shifts due to Donnan exclusion effects, band broadening (due to a large dead volume and high dispersion), and oxidation of nitrite, which is easily oxidized to nityrate, due to the formation of nitrous acid in the suppressor. Because of these limitations, they were only practical for isocratic elution. However, the main disadvantage of the method is the necessity for periodical regeneration of the suppressor (also called stripper) to restore its ion-exchange capacity. 

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