Nitrothiazoles, synthesis

This reaction is convenient for preparative synthesis, since it can be conducted in a single stage [529], cc-Halogeno-cc-nitro ketones are also used for the synthesis of 5-nitrothiazoles [213] (Scheme 88). 

In a development stage, when we had data for only 8-10 points meaningful correlations were still possible. Thus, equations analogous to Equation 5 have been effective guides to further synthesis of nitrothiazoles possessing high activity in vitro. 

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