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Nitrosoarenes reaction with glutathione

The reaction of N-oxygenated drugs and metabolites with glutathione may also have toxicological and medicinal implications. Thus, the addition of GSH to nitrosoarenes, probably followed by rearrangement, forms sulfinamides (reaction 9), which have been postulated to contribute to the idiosyncratic toxicity of a few drugs such as sulfonamides... [Pg.463]

Figure 25. Proposed mechanism for the reaction of nitrosoarene compounds with sulfhydryl groups. (GIu-SH is reduced glutathione Glu-S-S-Glu is oxidized glutathione). Figure 25. Proposed mechanism for the reaction of nitrosoarene compounds with sulfhydryl groups. (GIu-SH is reduced glutathione Glu-S-S-Glu is oxidized glutathione).
See other pages where Nitrosoarenes reaction with glutathione is mentioned: [Pg.360]    [Pg.1000]    [Pg.1019]    [Pg.330]    [Pg.331]    [Pg.350]    [Pg.171]    [Pg.172]    [Pg.1009]    [Pg.340]   
See also in sourсe #XX -- [ Pg.1021 , Pg.1023 , Pg.1025 , Pg.1027 , Pg.1028 , Pg.1029 , Pg.1030 ]



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