Nitroisothiazoles, Nitrothiazoles, and Nitrothiadiazoles

The spectra of 16 isothiazole derivatives including 4-nitroisothiazoles have been examined [1324], Electron impact induces cleavage of the S-N bond and abstraction of a fragment of type R3CN or HCN occurs [1324], 

The base fragmentation peaks of 4-methyl-5-nitrothiazol-2-yl derivatives of urea and thiourea [1165] and 4-substituted 2-halogen-5-nitrothiazoles [546] are discussed. 

2-Amino-5-nitrothiazole is widely used as effective matrixes in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) study of oligonucleotide and protein [1326], 

The fragmentation proceeds in a manner typical for unsaturated 1,2,3-thiadiazoles however, an N2 evolution takes place and the generated ion loses either the hydroxy radical or the N02 group [1327], 

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