Nitrogen nanomolar concentrations

A large number and diverse classes of compounds have been reported to possess tyrosinase inhibitory activities to various extents from the millimo-lar to nanomolar concentration ranges. From our laboratory we have also reported a large variety of tyrosinase inhibitors and for some of them we have performed molecular modeling as well. Among them there are several alkaloids, and nitrogen-containing molecules are also present. 

Nitrogen monoxide, formed in vivo at nanomolar concentrations, acts as a messenger for the relaxation of blood vessels. At higher concentrations, produced by macrophages during the immune response, it may damage proteins and membranes by the way of peroxynitrite (Herold 2001). 

Harrison, W. G., Harris, L. R., Irwin, B. D. (1996). The kinetics of nitrogen utilization in the oceanic mixed layer Nitrate and ammonium interactions at nanomolar concentrations. Eimnol. Oceanogr. 41, 16-32. 

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