Nitrogen-containing heterocydes

Fragment ions All nitrogen-containing heterocydics lose HCN and/or H2CN from their molecular ions. 

The oxygen- or nitrogen-substituted allene adducts as described in the previous section are of major interest because of the possible subsequent cyclization leading to very valuable oxygen- or nitrogen-containing heterocydes (Scheme 8.25). The syn-... 

M-Oxides. The reagent also reacts with aromatic nitrogen-containing heterocydes to give high yields of N-oxides (90-100%). However, 2,2 -bipyridyl and o-phenanthro-line are not oxidized. 

Whereas the catalytic hydrosilylation of alkynes was one of the first methods of controlled reduction and functionalization of alkynes, the ruthenium-catalyzed hydroamination of alkynes has emerged only recently, but represents a potential for the selective access to amines and nitrogen-containing heterocydes. It is also noteworthy that, in parallel, the ruthenium activation of inert C-H bonds allowing alkyne insertion and C-C bond formation also represents innovative aspects that warrant future development. Among catalytic additions to alkynes for the production of useful products, the next decade will clearly witness an increasing role for ruthenium-vinylidenes in activation processes, and also for the development of ruthenium-catalyzed hydroamination and C-H bond activation. 

In contrast, the amido and the sulfamidomercuration-demercuration of acyclic 1,4- and 1,5-dienes yield saturated nitrogen-containing heterocydes (equation 169) ... 

Reid, S. T., The Photochemistry of Heterocydes, 11, I The Photochemistry of Oxygen- and Sulfur-Containing Heterocydes, 33, I Photochemistry of Nitrogen-Containing Heterocydes, 30, 239. 

Besson T, Thi4ry V (2006) Microwave-2 isted Synthesis of Sulfur and Nitrogen-Containing Heterocydes. 1 59-78... 

Microwave-Assisted Synthesis of Sulfur and Nitrogen-Containing Heterocydes... 

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