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Nitrogen compounds ester hydrolysis

Examples of kinetic resolutions with lipases are numerous [9], Impressive enantioselectivities are often obtainable with secondary alcohols, e.g., in acetylations with vinyl acetate, or in hydrolysis of the racemic ester. Likewise, the corresponding amines can be resolved, e.g. by enantioselective acetylation with EtOAc as both acyl donor and solvent. This has been demonstrated by Gotor and coworkers using Novozym 435 [50]. The reaction (Scheme 13.3) follows Kazlauskas selectivity. In fact an impressive range of CALB (Novozym 435) catalyzed transformations on nitrogenated compounds have been collected in a recent review article [51]. [Pg.376]

Procedures for shipping boric acid esters depend on the particular compound. Aryl borates produce phenols when in contact with water and are therefore subject to shipping regulations governing such materials and must carry a Corrosive Chemical label. Lower alkyl borates are flammable, flash points of methyl, ethyl, and butyl borates are 0, 32, and 94°C, respectively, and must be stored in approved areas. Other compounds are not hazardous, and may be shipped or stored in any convenient manner. Because borate esters are susceptible to hydrolysis, the more sensitive compounds should be stored and transferred in an inert atmosphere, such as nitrogen. [Pg.215]

Dimethylaminoethane-2-ol (20) is a compound that, by virtue of its nucleophilic center (Me2NH+C2H40), is employed to convert protected segments bound to supports as benzyl esters into acids by transesterification into dimethylaminoethyl esters [C(=0)0C2H4NMe2] that are hydrolyzable by a dimethylformamide-water (1 1) mixture. Compound 20 readily forms esters from acid chlorides. The hydrolysis and esterification are facilitated by anchimeric assistance by the adjacent nitrogen atom (see Section 2.10). The amino alcohol also reacts with dichloromethane. [Pg.269]


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See also in sourсe #XX -- [ Pg.456 ]




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Hydrolysis compounds

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