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Nitrogen-aryl bond, Buchwald-Hartwig amination

Amines are generally prepared by nucleophilic amination, which is a coupling of carbon electrophiles with a nucleophilic amination reagent, NR2, and Ni and Pd catalyzed reaction of aryl halides with arylamines (Hartwig-Buchwald amination) . Thus, the direct C—N bond formation between carbon nucleophiles and electrophilic nitrogen functionality R2N+ constitutes an example of the umpolung methodology. [Pg.304]

The seminal work by the groups of Hartwig and Buchwald in 1994 on aryl amina-tion chemistry has spurred substantial research on C-N bond formation in general and aryl-nitrogen bond formation in particular [114]. Catalytic aryl amine couplings are usually slow processes, especially when copper catalysis is used, often... [Pg.708]


See other pages where Nitrogen-aryl bond, Buchwald-Hartwig amination is mentioned: [Pg.564]    [Pg.36]    [Pg.52]    [Pg.24]    [Pg.995]    [Pg.116]    [Pg.1364]    [Pg.1051]    [Pg.1055]    [Pg.513]    [Pg.24]   
See also in sourсe #XX -- [ Pg.564 ]




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Amination, aryl

Amines arylation

Aryl Bonds

Aryl aminations

Aryl amines

Bonding amines

Bonding aryls

Buchwald-Hartwig

Buchwald-Hartwig amination

Buchwald-Hartwig aminations

Buchwald-Hartwig aryl amination

Buchwald—Hartwig amine

Buchwald—Hartwig amine arylation

Buchwald—Hartwig arylations

Hartwig

Nitrogen amines

Nitrogen arylation

Nitrogen-aryl bond, Buchwald-Hartwig

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