Nitroaldol reactions tandem inter-intramolecular asymmetric

F. Tandem inter-intramolecular catalytic, asymmetric nitroaldol reaction... 

Catalytic, Asymmetric Tandem Inter-Intramolecular Nitroaldol Reaction of98 with... 

Tandem Inter-Intramolecular Catalytic Asymmetric Nitroaldol Reaction... 

The asymmetric catalytic nitroaldol reaction was furthermore successfully extended to the field of asymmetric tandem reactions [31]. Tandem reactions are especially useful to construct compounds with several chiral centers in a one-pot synthesis starting from simple achiral components in the presence of a chiral catalyst. The first tandem inter-intramolecular catalytic asymmetric nitroaldol reaction has been realized in the reaction of the cyclopentanedione derivative 34 with nitromethane using a catalytic amount of LnLB according to Scheme 8 [31]. 

Figure 28. Proposed mechanism for the tandem inter- and intramolecular catalytic asymmetric nitroaldol reaction.

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