Nitriles acylation, Reformatsky reagents

The most successful acylations of Reformatsky reagents have been obtained with nitriles. This reaction, first reported in 1901 by Blaise, was little used until Kagan and Suen reported that slow addition of a benzene solution of a-bromo esters to a refluxing mixture of zinc and the nitrile gave good yields (70-83%) of a,a-disubstituted 3-keto esters. Hannick and Kishl reported that a similar proce-... 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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