Nitrazepam Rifampicin

Rifampicin causes a very marked increase in the metaboiism and/or ciearance of diazepam and nitrazepam. Rifampicin aiso causes a marked increase in the ciearance of midazoiam and tria-zoiam and the non-benzodiazepine hypnotics, zaiepion, zoipidem andzopicione. Benzodiazepines and reiated drugs that are metabolised similarly are expected to interact in the same way. 

BZDs, NOT LORAZEPAM, OXAZEPAM, TEMAZEPAM RIFAMPICIN 1 BZD levels Induction of CYP3A4-mediated metabolism Watch for poor response to these BZDs consider increasing the dose, e.g. diazepam or nitrazepam 2-3-fold... 

A study in healthy subjects found that rifampicin 600 mg daily for 7 days increased the total body clearance of nitrazepam by 83%." ... 

The documentation of these interactions is limited but what has been reported is consistent with the way rifampicin interacts with many other drugs. The clinical importance of some of these interactions between the benzodiazepines and related drugs and rifampicin has not yet been assessed but what is known suggests that the dosage of diazepam and nitrazepam may need to be increased if rifampicin is given. Be alert for a reduction in the effects of other similarly metabolised benzodiazepines (e.g. chlordiazepoxide, flurazepam). 

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See also in sourсe #XX -- [ ]

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