Nitidine, topoisomerase inhibition

Another application of the cro,ss-coupling reaction is demonstrated in Scheme 10-3 with an efficient synthesis [13] of the precursor of an alkaloid, nitidine, which inhibits DNA topoisomerase I. 

Fagaronine and nitidine from Zanthoxylum species represent two of the more potent antitumor benzo[c]phenanthridines of Rutaceae. Both of these alkaloids have been shown to inhibit the enzymatic activity of topoisomerase in a way similar to camptothecin (28,29). It would be interesting to learn whether further study on Z. ailanthoid.es Sieb. Zucc. discloses any benzo[c]phenanthridine alkaloid of anti-neoplastic value. 

Wang LK, Johnson RK, Hecht SM. Inhibition of topoisomerase I function by nitidine and fagaronine. Chem Res Toxicol 1993 6 813-818. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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