Nicotinic acetylcholine receptors schematic

A FIGURE 7-45 Three-dimensional structure of the nicotinic acetylcholine receptor, (a) Schematic cutaway model of the pentameric receptor in the membrane for clarity, the p subunit is not shown. Each subunit contains an M2 a helix (red) that faces the central pore. Aspartate and glutamate side chains at both ends of the M2 helices form two rings of negative charges that help exclude anions from and attract cations to the channel. The gate, which is opened by binding of acetylcholine, lies within the pore, (b) Top Cross section of the exoplasmic face of the... 

Fig. 17.3 A schematic representation of (nicotinic) acetylcholine receptor (from Dougherty DA and Lester HA (2001) Nature 411 252-25)...

Figure 3. Schematic representation of nicotinic acetylcholine receptors. Side (A) and top (B) views ofheteromeric and homomeric nicotinic receptors. Loops A-F forming the agonist binding site of heteromeric receptors and key amino acid residues that have been shown to contribute to the agonist binding are also illustrated in B. Abbreviation ACh, acetylcholine. Reproduced from Ref. 10 with permission of Elsevier. (See page 2 of color insert.)...

Fig. 1. Schematic drawing of the cholinergic neurotransmission. In case of ganglionic and neuro-muscular synapses, the receptor is of the nicotinic, sodium channel-coupled type, in case of synapses at the parasympathetic target organs, the receptor is of the muscarinic, G-protein-coupled type. The predominant ehinination pathway of the transmitter acetylcholine...

Schematic diagram comparing some anatomic and neurotransmitter features of autonomic and somatic motor nerves. Only the primary transmitter substances are shown. Parasympathetic ganglia are not shown because most are in or near the wall of the organ innervated. Cholinergic nerves are shown in blue noradrenergic in red and dopaminergic in green. Note that some sympathetic postganglionic fibers release acetylcholine or dopamine rather than norepinephrine. The adrenal medulla, a modified sympathetic ganglion, receives sympathetic preganglionic fibers and releases epinephrine and norepinephrine into the blood. ACh, acetylcholine D, dopamine Epi, epinephrine M, muscarinic receptors N, nicotinic receptors NE, norepinephrine.

Figure 6-1. Schematic diagram comparing some features of the parasympathetic and sympathetic divisions of the autonomic nervous system with the somatic motor system. Parasympathetic ganglia are not shown as discrete structures because most of them are diffusely distributed in the walls of the organs innervated. ACh, acetylcholine Epi, epinephrine NE, norepinephrine, D, dopamine N, nicotinic M, muscarinic a, p, alpha and beta adrenoceptors D, dopamine, receptors. (Reproduced, with permission, from Katzung BG [editor] Basic Clinical Pharmacology, 8th ed. McGraw-Hill, 2001.)...

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