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Nicotine metabolism CYP2A6 activity

Rahnasto, M., Raunio, H., Poso, A., Wittekindt, C., Juvonen, R.O. Quantitative structure-activity relationship analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme, J. Med. Chem. 2005,48,440-9. [Pg.80]

Kidney failure not only decreases renal clearance of nicotine and cotinine, but also metabolic clearance of nicotine (Molander et al. 2000). Metabolic clearance of nicotine is reduced by 50% in subjects with severe renal impairment compared to healthy subjects. It is speculated that accumulation of uremic toxins may inhibit CYP2A6 activity or downregulate CYP2A6 expression in liver. Hepatic metabolism of several drugs is reduced in kidney failure, mainly via downregulation of CYP enzymes and/or inhibition of transporters (Nolin et al. 2003). [Pg.43]

Mwenifumbo JC, Sellers EM, Tyndale RF (2007b) Nicotine metabolism and CYP2A6 activity in a population of black African descent Impact of gender and light smoking. Drug Alcohol Depend 89 24-33... [Pg.255]

See other pages where Nicotine metabolism CYP2A6 activity is mentioned: [Pg.266]    [Pg.42]    [Pg.38]    [Pg.43]    [Pg.44]    [Pg.45]    [Pg.46]    [Pg.237]    [Pg.238]    [Pg.238]    [Pg.239]    [Pg.239]    [Pg.240]    [Pg.243]    [Pg.245]    [Pg.246]    [Pg.247]    [Pg.249]    [Pg.257]    [Pg.257]    [Pg.266]    [Pg.270]    [Pg.90]    [Pg.597]    [Pg.599]    [Pg.210]    [Pg.403]    [Pg.628]    [Pg.42]    [Pg.243]    [Pg.122]    [Pg.626]    [Pg.231]    [Pg.7]    [Pg.474]    [Pg.66]    [Pg.87]    [Pg.836]    [Pg.45]   
See also in sourсe #XX -- [ Pg.239 , Pg.240 ]



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