Nickel catalyzed cross Sonogashira coupling

Other successful examples of catalysts containing NHC ligands are found in palladium- and nickel-catalyzed carbon-carbon bond formations. The catalyst development with these metals has focused in particular on Heck-type reactions, especially the Mizoroki-Heck reaction itself [Eq. (42)] and various cross coupling reactions [Eq. (43)], e.g., the Suzuki-Miyaura reaction ([M] = and the Kumada-Corriu reaction ([M] = MgBr). " Related reactions like the Sonogashira coupling [Eq. (44)]326-329 Buchwald-... [Pg.42]

The final step in Scheme 69 is similar to that suggested for nickel or palladium-catalyzed cross-coupling of terminal alkynes with chlorophosphines to give phos-phinoalkynes. After P-Cl oxidative addition, Sonogashira-style formation of a metal-alkynyl group and P-C reductive elimination were proposed [123, 124]. [Pg.96]