Reserpine Nialamide

Krnjevic and Videk ) described a new screening test based on a "natural reaction of a rat, namely the entrance into a darkened cage through a hole of suitable size (5 cm. ). Either of several depressants, chlorpromazine, reserpine, phenobarbital, etc. increased the time required for this reaction. A pyschostimulant, amphetamine, decreased the time, as did the anti-depressants imipramine or nialamide. 

A woman with a history of manic depression who had been in a depressed phase for 5 years was given nialamide 100 mg three times daily. Two days later, reserpine 500 micrograms three times daily was also started. The following day she became frankly hypomanic and almost immediately went into mania. ... 

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