Chest pain niacin

Heart disease People with heart disease, particularly those who have recurrent chest pain (angina) or who recently suffered a heart attack, should take niacin only under the supervision of a health care provider. 

One large and five small randomized clinical trials showed decreased cardiovascular events (heart attacks, serious episodes of coronary chest pain, and cerebrovascular events) with niacin or combination therapy including niacin. 

Niacin has also been trialled in combination with a statin and its safety compared with a statin alone [64 ]. Flushing occurred in 67% of patients and was the most common treatment-related adverse effect 21% of patients stopped taking niacin for a variety of symptoms and the incidence of adverse effects apart from flushing was 85%. There were three cases of chest pain, which were regarded as serious adverse events. Gastrointestinal discomfort was not uncommon. Fasting blood glucose concentrations rose by 7.7% over the 12 weeks of the study. In contrast in another study there was improved whole-body insulin sensitivity in an open study over 6 months [65 ]. 

Leighton RF, Gordon NF, Small GS, Davis WJ, Ward ES Jr. Dental and gingival pain as side effects of niacin therapy. Chest 1998 114 1472-4. 

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See also in sourсe #XX -- [ ]

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