Ni-catalyzed three-component coupling reaction

Ni-catalyzed multi-component coupling reactions are an efficient protocol for carbon-carbon bond formation [97]. The Ni-catalyzed asymmetric intermolecular reductive coupling of 1,3-dienes and aldehydes with Et Zn as a reducing reagent was realized [Pg.87]

Zhou et al. [99] developed a Ni-catalyzed reductive coupling of alkynes and imines with Et Zn as a reductant by using electron-rich spiro phosphine ligands, which afforded various allylic amines with high yields and excellent chemoselec-tivities. The asymmetric version of this reaction was also accomplished by using [Pg.88]