New Chiral Stationary Phases and Information Management Software

New Chiral Stationary Phases and Information Management Software 

In the forthcoming years, the development of new chiral phases for HPLC will remain a dynamic topic for research in industry and academia. 

More immobilized cellulose and amylose phases are currently tmder development at Daicel. Daicel is promoting the concept of a CSP library of more than 100 stationary phases that are not currently commercially available, which can be screened for enantiomer separations. Astec has recently presented an improved linking of antibiotic phases (Chirobiotic). As yet, no chiral monolithic stationary phases are commercially available, although one can assume that various companies are currently endeavoring to change the surface of monolithic material with chiral modifiers. 

The group of Prof. Roussele in Marseille has been working for the past ten years on the assembly of a database for enantiomer separations in HPLC and GC called Chirbase [47]. So far, more than 100,000 enantiomer separations of more than 30,000 compounds have been described every three months another 5000 entries are being added, some of which have not been published in the open literature. 

Enantioselective HPLC has evolved in recent years to a routine method carried out on analytical, preparative, and industrial scale. The optimization of separations 

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