New Acyclic Nitrone Spin Traps

Refs 16, 60, 75 Commercially available. Methods to remove contaminating hydroxylamines present in some commercial samples given in ref. 76 

LO /LOO-, RNH-, acyl, 803--, SO/, protein-derived carbon-, oxygen- and sulfur-centred 

Lifetime of superoxide radical adduct relative to DMPO  

Half-life significantly greater in organic solvents e.g. DMSO, DMF ) 

Single diastereoisomer formed in most cases e.g. HO% RS% RjC ) due to diethoxyphosphoryl group being pseudoaxial and blocking one face second diastereoisomer formed in some cases. adduct undergoes conformational 

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New Acyclic Nitrone Spin Traps. - The range of new acyclic nitrone traps that have been synthesised is more limited than that of the related cyclic materials. Examples of some of these new materials are given in Scheme 3. This is due, at least in part, to the perception that these traps provide more limited data in terms of the range of hyperfine coupling constants than the cyclic nitrones, and hence decreased opportunities for definitive identification of radical adducts. Nonetheless these traps can have considerable advantages in that they often yield very persistent adducts, which can be of major benefit in determining whether a process is radical-mediated or not, before more intensive study to determine the exact nature of the species involved. This persistence is of major importance when the separation and subsequent identification (by other... 

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