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Neutral competitive antagonist

Such a ligand, however, will reduce the action of either a conventional or an inverse agonist, and so in effect is an antagonist. More precisely, it is a neutral competitive antagonist. If large... [Pg.33]

Thomas A, Ross RA, Saha B, Mahadevan A, Razdan RK, Pertwee R (2004) 6 -Azidohex-2 -yne-cannabidiol a potential neutral, competitive cannabinoid CBl receptor antagonist. Eur J Pharmacol 487 213-221... [Pg.50]

A series of prodrug candidates (517) of the known competitive A-methyl-D-aspartate (NMDA) antagonist (516) has been designed and prepared in an attempt to improve the oral bioavailability of that compound. The diphenyl analogue (R = Ph) demonstrated a good stability at acidic and neutral pH, as well as in simulated gastric fluid. In rat plasma, this analogue was rapidly converted to (516) (Scheme 135). ... [Pg.276]

See other pages where Neutral competitive antagonist is mentioned: [Pg.34]    [Pg.66]    [Pg.353]    [Pg.3115]    [Pg.77]    [Pg.116]    [Pg.460]    [Pg.917]    [Pg.249]    [Pg.77]    [Pg.191]    [Pg.206]    [Pg.250]    [Pg.255]    [Pg.400]    [Pg.547]    [Pg.304]    [Pg.375]    [Pg.97]    [Pg.283]    [Pg.300]    [Pg.24]    [Pg.196]    [Pg.2995]    [Pg.467]    [Pg.1494]    [Pg.162]    [Pg.569]    [Pg.280]    [Pg.282]    [Pg.287]    [Pg.288]    [Pg.29]    [Pg.394]   
See also in sourсe #XX -- [ Pg.33 , Pg.97 ]



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