Neuropeptides binding mode

Similarly, a three-dimensional model of the vasopressin/oxytocin receptor has been defined and the binding mode of the neuropeptides has been analysed (Figure 3 and 5). Residues likely to contribute to the affinity, efficacy and selectivity have been proposed from the model. These qualitative predictions have subsequently been confirmed by site directed mutagenesis [20-22]. A number of general comments can be made ... 

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