Neurological Disorders and Pain

The value of high-resolution characterization of neuropeptides may be seen in some studies undertaken in this laboratory into the possible 

In these pain studies, the next question to be answered concerns the origin of these increased enkephalin levels Are they biosynthesized directly or do they arise by metabolism of some larger, perhaps biologically inactive, protein Over the past few years many excellent studies on the isolation and characterization of enkephalin precursors have been reported, with reverse-phase HPLC playing a major part in the purification of both the macrolecules themselves and their enzymically generated fragments (e.g., Rossier et aL, 1980 Kimura et a/., 1979 Rubenstein et al.y 1978 Lewis et ai, 1979 Lariviere et ai, 1980 Beaumont et a/., 1980). 

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