Neuroleptics, 1-benzazepines

The benzazepines are not as important pharmacologically as their more famous relatives the benzodiazepines. However, 3-aryl-2-(piperazin-l-yl)-5//-l-benzazepines, e.g. 14, and 17/-3-benzazepin-2-amines 15 possess neuroleptic activity,60 and antihypertensive activity,45 61 respectively. 

Remy, D.C., Britcher, S.F., King, S.W., Anderson, P.S., Hunt, C.A., et al. (1983) Synthesis and receptor binding studies relevant to the neuroleptic activities of some l-methyl-4-pipeiidylcnc-9-substi-tuted-pyrrolo[2,l-i>][3]benzazepine derivatives. J. Med Chem. 26 974-980. 

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